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投稿时间：2022-03-09
投稿时间：2022-03-09
中文摘要: 嗜黏蛋白阿克曼氏菌（Akkermansia muciniphila）被认为是下一代益生菌，在宿主体内的丰度与结肠炎、糖尿病、肥胖、动脉粥样硬化等诸多疾病呈负相关。该文综述A.muciniphila的基本生理特性、活性功能及关键蛋白的研究进展，总结A.muciniphila对多种母乳寡糖的代谢能力及代谢产物对婴儿肠道微生物群的影响，以及外膜蛋白Amuc_1100的特性和生理功能，为阐明A.muciniphila在婴儿肠道健康中的作用机制和深度开发提供依据。
中文关键词: 嗜黏蛋白阿克曼氏菌 外膜蛋白Amuc_1100 母乳寡糖 糖苷酶 婴儿肠道健康
Abstract:Akkermansia muciniphila was considered as the next generation probiotics，the abundance of which in the host is negatively correlated with colitis，diabetes，obesity，atherosclerosis and many other diseases.This paper summarized the research progress on basic physiological characteristics，biological activities，and functional proteins of A.muciniphila，and its ability to metabolize human milk oligosaccharides and the effects of metabolites on infant intestinal microbiota.The characteristics and physiological functions of outer membrane protein Amuc_1100 were also described here.This review provided a theoretical basis for further exploring the interaction mechanism among A.muciniphila and infant intestinal health.
keywords: Akkermansia muciniphila outer membrane protein Amuc_1100 human milk oligosaccharides glycosidase infant intestinal health
文章编号：202221025 中图分类号： 文献标志码：
基金项目:国家自然科学基金（31872893）
| Author Name | Affiliation |
| GAO Wei，FU Xiao-dan，GU Zi-qiang，ZHU Chang-liang，XIAO Meng-shi*，MOU Hai-jin* | College of Food Science and Engineering，Ocean University of China，Qingdao 266003，Shandong，China |
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