Abstract:To optimize the extraction technology for total flavonoids from Rose roxburghii.According to the results of the single-factor experiment and the central composite experimental design principles，a response surface methodology which had three factors and three levels was designed to optimize the extraction technology for total flavonoids form Rose roxburghii.The effect of different drying methods（drying under the sun，drying in the shade，oven drying，microwave drying and freeze drying）on extraction rate was analyzed comparatively under the optimal conditions.The extraction rate of total flavonoids at 10.76%was achieved under the optimal conditions：65%ethanol was used as extraction solvent with the ratio of 1 ∶71（g/mL）raw material to liquid，the reflux extraction time was 115.5 min.