Abstract:The effect of Poria cocos on the improvement of learning and memory function of mice was investigated.A total of 130 Kunming mice were randomly divided into negative control group；low-dose and high-dose group of raw Poria cocos powder；low-dose and high-dose group of cooked Poria cocos powder；low-dose and highdose group of Poria cocos surrogate culture powder；low-dose，medium-dose and high-dose group of Poria cocos water extract；low-dose，medium-dose and high-dose group of Poria cocos alcohol extract.Each group comprised 10 mice，and they receive continuous gavage for 30 days，once a day.On the second day after the last gavage administration，the effects of Poria cocos on the improvement of learning and memory function of mice were evaluated using water maze experiment，diving platform experiment and avoid dark experiment.Results showed that Poria cocos could significantly（all P<0.05）enhance memory function of mice，reduce their error response rate in the diving platform experiment，reduce their memory fading，prolong their latency period in the diving platform experiment and reduce their error response rate in the avoid dark experiment in mice）.Poria cocos could improve the function of learning and memory in mice.