Abstract:To investigate the hypoglycemic efficacy of defatted Antarctic krill powder proteolytic peptides（DAKP） on diabetic mice， a type 2 diabetic mice model was built by high-sugar and high-fat diet combined with intraperitoneal injection of streptozotocin. The model mice were subjected to a 6-week intervention treatment with DAKP. During this period， related indicators of glucolipid metabolism and hepatorenal functions were measured， and histopathological morphological changes were observed. The results showed that DAKP could significantly reduce fasting blood glucose levels， and improve glucose tolerance and insulin resistance in diabetic mice； the content of total cholesterol， triglyceride， and low-density lipoprotein cholesterol was reduced by 27.51%， 46.67%， and 52.71%， respectively， indicating alleviation of abnormal lipid metabolism；the activities of alanine aminotransferase and aspartate aminotransferase were decreased by 63.00% and 35.90%， while the content of urea nitrogen and creatinine was decreased by 28.29% and 51.06%， respectively， suggesting mitigation of hepatorenal function impairment. At the same time， DAKP effectively alleviated tissue damage in the liver， kidneys， and pancreas in diabetic mice. Therefore， DAKP has hypoglycemic efficacy， able to mitigate abnormal glycolipid metabolism and hepatorenal function impairment induced by type 2 diabetes mellitus and repair tissue damage in diabetic mice. These findings suggest that DAKP can be used as a potential functional food ingredient for the treatment of diabetes and its complications.