Abstract:Yeast β-glucan is the polysaccharide extracted from yeast， with β-1，3-glucan as the backbone. It has been approved as a new food ingredient and it is widely applied in the food and biological industries. In vitro and in vivo experiments， as well as clinical trials， have demonstrated yeast β-glucan to be an immunomodulator and prebiotic. Therefore， the biological activities of yeast β-glucan， including immunomodulation， intestinal health improvement， glycolipid metabolism regulation， and antioxidant properties， were summarized. In addition， the application of yeast β-glucan in the food industry was reviewed， with the aim of providing theoretical references for the development of health products with yeast β-glucan.