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投稿时间:2023-12-20
投稿时间:2023-12-20
中文摘要: 糖尿病患者多为2 型糖尿病(type 2 diabetes mellitus,T2DM),伴有胰岛素抵抗和胰岛素分泌缺陷。T2DM 的治疗策略一般为控制饮食、适度运动、服用降糖降脂药物等。尽管治疗T2DM 的药物具有一定的治疗效益,但大多数药物可产生一些不良副作用。越来越多的研究表明,植物中的天然产物如多酚、多糖、皂苷等具有降血糖和调节糖代谢紊乱的作用。该文通过总结天然产物降血糖及膳食多酚抗T2DM 的作用及机制的研究进展,探讨其在糖尿病治疗中的应用潜力,为降血糖功能性食品的研究与开发奠定理论基础。
Abstract:The majority of diabetic patients suffer from type 2 diabetes mellitus(T2DM),which is characterized by insulin resistance and insulin secretion deficiency. The common therapeutic strategies for T2DM include dietary control,moderate exercise,and the use of glucose-and lipid-lowering drugs.Although the medications for T2DM offer therapeutic benefits,most of them can cause adverse side effects. An increasing number of studies have demonstrated that natural products in plants,such as polyphenols,polysaccharides,and saponins,possess the effects of lowering blood glucose and regulating glucose metabolism disorders. The recent advances in the research on the blood glucose-lowering effects of natural products and the anti-T2DM mechanisms of dietary polyphenols were reviewed. The potential applications of these natural products in the treatment of diabetes were explored,which provided a theoretical foundation for the research and development of functional food for lowering blood glucose.
keywords: type 2 diabetes mellitus natural products dietary polyphenols insulin resistance glucose metabolism
文章编号:202505029 中图分类号: 文献标志码:
基金项目:石河子大学2023 年度自主资助支持校级科研项目(ZZZC2023100);新疆维吾尔自治区高校科研计划项目(XJEDU2023J031);新疆维吾尔自治区自然科学基金面上项目(No. 2022D01A100)
作者 | 单位 |
张姣姣1,马壮2,何大俊1,王灏3,李艳红4* | 1.石河子大学分析测试中心,新疆 石河子 832003;2.新疆理工学院,新疆 阿克苏 843100;3.新疆师范大学体育学院,新疆 乌鲁木齐 830054;4.新疆师范大学生命科学学院,新疆 乌鲁木齐 830054 |
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