Abstract:To provide theoretical basis and practical guidance for solving the obesity problem of young people，this study compared the differences in satiety and blood glucose response changes between nutritional protein meal replacement and traditional rice flour. The study subjects were 10 overweight women aged 18-35 years who met certain body mass index （BMI） and body fat percentage standards. With a randomized，double-blind，crossover design，nutritional protein meal replacement and rice flour having the same volume and energy were tested successively，and the visual analogue scale （VAS） method and a glucose meter were utilized to evaluate the satiety scores and blood glucose responses of the two test meals for 240 min. The results showed that the change in satiety level was significantly higher in the nutritional protein meal replacement group than in the rice flour group from 120 to 240 min （P<0.05，P<0.01，P<0.001）. The peak blood glucose level in the nutritional protein meal replacement group was significantly lower than that in the rice flour group，and the incremental area under the curve （IAUC） in the nutritional protein meal replacement group was significantly lower than that in the rice flour group at 0-90 min and 0-240 min（P<0.05）. In conclusion，the nutritional protein meal replacement was able to provide a more sustained level of satiety and a smoother blood glucose response than the rice flour.