Abstract:To improve the yield of polysaccharides from the volva of Dictyophora rubrovalvata，this study prepared D.rubrovalvata polysaccharide effervescent tablets and investigated the effects of extraction time，extraction temperature，solid-to-liquid ratio，and extraction power on the yield of polysaccharides.Extraction conditions of polysaccharides from the volva of D.rubrovalvata were optimized by response surface methodology（Box-Behnken design）based on single factor experiments.The effervescent tablets were prepared with the extracted polysaccharides as raw materials by the method of acid-base separate granulation and mixed tableting.The results showed that the optimum extraction conditions were determined as follows：extraction time of 51 min，extraction temperature of 60 ℃，solid-to-liquid ratio of 1∶48（g/mL），and extraction power of 400 W.Under these conditions，the maximum polysaccharide yield of 13.86% was obtained.The optimum proportions of raw and auxiliary materials for the preparation of effervescent tablets were as follows：2% polysaccharides of D.rubrovalvata，45% effervescent disintegrants，acid-base（citric acid∶sodium bicarbonate）ratio of 1.5∶1，2% adhesives（3% PVP solution），2% lubricants（PEG 6000），and 1% sweetener（aspartame）.The quality of the effervescent tablets was stable and the reproducibility was good，which conformed to the requirements of the 2020 edition of Chinese Pharmacopoeia.