Abstract:Constipation is a common condition that severely affects the quality of life of patients.There are several critical factors associated with normal intestinal motility，including the immune system，nervous system function，short-chain fatty acid content，and intestinal microbiota composition.Imbalance or dysfunction of any of these factors can lead to abnormal intestinal motility and subsequently the symptoms of constipation.Recently，numerous studies have found that probiotics contribute to the development and stability of the intestinal nervous system.Moreover，probiotics improve the microbial composition and concentration of short-chain fatty acids in the intestinal environment，thereby alleviating the symptoms and disease burden of constipation in patients.This paper summarizes and examines the mechanism and research progress of probiotics used in the treatment of constipation to improve the enteric nervous system and intestinal microbial environment.