Abstract:This study explored the different organic-acid metabolites in the liver of hyperlipidemic mice pretreated with compound dried tea，and investigates the effect of compound green tea on organic-acid metabolism in mice.Thirty male KM mice were randomly divided into a high-fat model group，a low-concentration compound tea group，and a high-concentration compound tea group.Metabonomics were used to observe the hepatic organic-acid metabolic pathways of high-fat diet mice.In all，121 organic acids and derivatives were detected；DL-glyceraldehyde-3-phosphate，dihydroxyacetone phosphate，（S）-2-hydroxybutyric acid，2-hydroxy-4-methylvaleric acid，D-hydroxypropionic acid and other metabolites were significantly downregulated in the high-concentration tea treatment group.In the low-concentration tea group，DL-glyceraldehyde-3-phosphate，dihydroxyacetone phosphate，（S）-2-hydroxybutyric acid，furfural and other metabolites were significantly downregulated，while ethyl hydroxyisohexanoate and caffeic acid N-oleoylglycine were upregulated.Among these，DL-glyceraldehyde-3-phosphate and dihydroxyacetone phosphate are related to gluconeogenesis and may play an important role in the decomposition of glycogen in hepatocytes and the maintenance of blood glucose homeostasis in vivo.The results showed that compound green tea can regulate the metabolic pathways（e.g.，glycolysis）of different organic-acid metabolites in hyperlipidemic mice，facilitating their change to normal state，and thereby alleviating the symptoms of metabolic disorder in hyperlipidemic mice.