Abstract:The present study explored the effects of chitooligosaccharide compound solid beverage（KSP）on intestinal microecology and the production of short-chain fatty acids（SCFA）in hyperuricemia mice.Mice were divided into a normal control group，a model group，low-，medium-，high-dose KSP groups and an allopurinol group.The hyperuricemia model was induced by intraperitoneal injection of potassium oxonate and intragastric administration of yeast extracts.The mice in the KSP groups were fed with fodder containing KSP.After 21 days，serum samples were collected to test the level of uric acid.The colonic and cecal contents were collected for SCFA detection and 16S rDNA high-throughput sequencing.The results showed that KSP could lower the uric acid level and regulate the relative abundance of Bacteroides，Alloprevotella，Prevotellaceae_UCG-001，Lactobacillus and Akkermansia in hyperuricemia mice.Additionally，KSP could also improve the abnormal increase in propionic acid，butyric acid，valeric acid and isovaleric acid induced by hyperuricemia.The findings of this study revealed that this chitooligosaccharide compound solid beverage could improve hyperuricemia by adjusting the composition of the intestinal flora and SCFA level.