Abstract:As an oxidoreductase，flavoprotein monooxygenase can catalyze the hydroxylation，Baeyer-Villiger oxidation，sulphoxidation，epoxidation，and halogenating reaction of various compounds.There are widely used in food，medicine and chemical industry.In this study，flavoprotein monooxygenases were reviewed in terms of the classification，biochemical characterization（including the expression condition optimization and the process control of catalytic reaction），protein engineering and application in the synthesis of functional food factors，respectively.In addition，the future development was also analyzed.