Abstract:Lactobacillus rhamnosus has been widely studied and applied due to its good probiotic characteristics. Extracellular polysaccharides，an important metabolite of L. rhamnosus，can act as postbiotics to exert various biological activities，such as antioxidant，anti-tumor，lipid-lowering，cholesterol-lowering，and intestinal barrier maintenance. The field of extracellular polysaccharides mediating and maintaining intestinal barrier homeostasis by L. rhamnosus is currently a research hotspot，and a summary of the related studies is of great significance. Therefore，this study summarized the relevant research on the intestinal barrier maintenance homeostasis mediated by extracellular polysaccharides of L. rhamnosus at home and abroad. A theoretical basis was thus expected to be provided for the further research and application of extracellular polysaccharides of L.rhamnosus as postbiotics in maintaining the intestinal barrier.