Abstract:In this paper，the tablet was prepared by wet granulation method with the powder of Polygonatum kingianum，Poria cocos，and Coix lacryma-jobi whose cell walls were physically broken as the raw material.Taking the sensory evaluation and disintegration time of the compound tablet as the comprehensive scoring index，this paper adopted the single factor and orthogonal test in determining the best formula for the buccal tablet.The Box-Behnken response surface methodology was used to optimize the preparation conditions and evaluate its content of active components and in vitro antioxidant activity.The results showed that the comprehensive score of the buccal tablets reached the highest when the mass ratio of Coix lacryma-jobi powder，Poria cocos powder and Polygonatum kingianum powder in raw materials was 3∶3∶1，the mass ratio of raw materials and auxiliary materials was 1∶4，the mass ratio of lactose and maltodextrin in auxiliary materials was 1∶1，the volume concentration of ethanol（moistening agent）was 70%，and 1.1% magnesium stearate was added after the materials were dried at 46 ℃for 25 min and sieved through 16 mesh. Under this condition，the polysaccharide content of the tablet was 104 mg/g，the flavonoid content was 3.17 mg/g. In vitro antioxidant tests showed that the scavenging rate of DPPH free radical，ABTS+ free radical，and hydroxyl free radical by 10 mg/mL water extract of the tablet was 23.2%，32.0%，and 45.0%，respectively，and the total reducing power was 0.191. Compared to vitamin C，0.4 mg/mL water extract of the tablet showed a weaker reducing power to Fe3+. In conclusion，the compound tablet with certain nutritional value not only had a well-formed shape and delicate taste but also was convenient for administration.