Abstract:The development of detection methods for antibiotic residues in animal-derived foods is of vital significance to food safety.However，the detection accuracy and sensitivity of trace antibiotic residues depend on the effect of sample pretreatment due to the strong matrix effect and diverse types of animal-derived foods.This recent research progress in the new adsorbents and new pretreatment methods for the ultra-sensitive detection of multiple antibiotic residues in animal-derived foods was reviewed.The review aims to provide solutions for rapid detection and accurate quantification of multiple antibiotic residues in animal-derived foods in the supervision of food safety.