Abstract:Combining extrusion and expansion technology with modern extraction and separation technology of phytochemicals.According to the characteristics of the homologous drug taste of the medicines and foods，polysaccharide extraction by water extraction and alcohol precipitation after the Hericium erinaceus was extruded and expanded by the twin screw extruder，the ketone sulfuric acid method was selected to determine the polysaccharide content.First，a single factor test was used to investigate the influence of the three factors of screw speed，moisture content，and extrusion temperature on the extraction rate of polysaccharides from Hericium erinaceus.After selecting the best level，the response rate of polysaccharide extraction rate was used to analyze the response surface.The method was further optimized to determine the optimal extrusion parameters for its polysaccharide extraction.The final optimization results was that screw speed was 400 r/min，moisture content was 16%，extrusion temperature was 120℃.Under the optimal process verification test，the yield was up to 3.63%，which was very close to the predicted value.It showed that the model established by response surface method had good predictability and can reasonably optimize the extraction process of extrusion pretreatment.