Abstract:Response surface methodology was employed to optimize the extraction yield of total flavonoids from Rosa chinensis.The ethanol concentration，extraction temperature，liquid-to-solid ratio and extraction time were used as four experimental factors with the extraction yield of total flavonoids as response value.A regression model for the yield of total flavonoids was established using a Box-Behnken design.The optimal extraction conditions were as follows：ethanol concentration was 60 %，extraction temperature was 87 ℃，liquid-to-solid ratio was 42 ∶1 （mL/g）and extraction time was 85 min.Under these conditions，the extraction yield of total flavonoids was 19.15 mg/g，which was consistent with the predicted results.