Abstract:Methanol was used as the extraction solvent to extract the polyphenols，and then the crude extract was separated and purified by solvent extraction and macroporous resin column.Single factor test and orthogonal array design were employed to analyze the effects of extraction temperature，solid to liquid ratio，methanol concentration，and extraction time on extraction efficiency and determine the optimum extraction process.Furthermore，the antioxidant activities of polyphenol extracts were assessed by DPPH，ABTS radical scavenging，total reduction force and oxygen radical absorbance capacity methods.Results：The maximum extraction efficiency of polyphenols was achieved after 2.5 h extraction using 50%methanol at a solid to solvent ratio of 1∶20 （g/mL）at 70℃.Compared with VC，polyphenols from Fructus terminaliae immaturus had a stronger antioxidant activity after extraction and purification，while ethyl acetate extract part of the polyphenol was the best.