Abstract:The method of simultaneous determination of 5 heavy metals （Ni， Pb， Cd， Cr， Cu） in Allium mon－ golicum regel by inductively coupled plasma mass spectroscopy （ICP-MS） was studied. The sample of Allium mongolicum regel after added into HNO3 and H2O2 was pre-processed by means of microwave dissolving tech－ nique. The experimental conditions of the microwave digestion sample were researched and the experimental pa－ rameters of ICP-MS were discussed and optimized. The results showed that the determined method of the simul－ taneous determination of 5 heavy metals in Allium mongolicum regel had good linear relationship （r=0.999 7-0.999 9）， the detection limit of the method was 0.0015 μg/L-0.010 1 μg /L， the relative standard derivation of the developed method was 1.3 % -3.4 %， its mean recovery was 97.85 % -100.09 %， the measured value of the standard matter in agreement with the standard value.