Abstract:Diet and genes are the two main factors that influence the occurrence and development of obesity. Cohort studies showed that the composition of intestinal flora in obese people was different from the general population， and this difference was one of the important causes of obesity. The current study found that diet is essential for shaping the intestinal flora. So it is more realistic to have a better effect on the occurrence and development of obesity through diet in the context of failing to dramatically change the composition of the host gene.