Abstract:A method for the simultaneous determination of 16 phthalate esters in food Containing Fat by Dispersive Solid Phase Extraction- Gas Chromatography-Mass Spectrometry ( d- SPE- GC- MS) was developed and evaluated． The samples were extracted with acetonitrile(saturated with hexane), and the extract was cleaned up by PSA d- SPE. The qualitative and quantitative analysis were used with SIM mode．The results showed that the average recoveries rate were in the range of 66.81%～101.55% at the spiked levels of 50 and 100 ug /kg; and the RSDs of precision were 3.72～9.6%．Precision,Sensitivity and Detection Limit meet the challenge of analysis. The method is simple,rapid,and accurate,which can improve work efficiency and reduce the cost.It can avoid the the large solvent consumption in the Usage of gel permeation chromatography.More importantly, disturbance of Instrument and reagent in experiment were decreased to a minimum.