Abstract:Biological preservatives are natural， safe and non -toxic， which can effectively inhibit the propagation of harmful bacteria， and maintain the original flavor and nutritional value of food. Therefore，research on biological preservatives has become the hotspot in the field of preservation in recent years. Herein the mechanisms of biological preservatives were introduced. The research status of several biological preservatives （chitosan， tea polyphenols， nisin， etc） in preservation of aquatic products were summarized. In addition， the problem and the future research direction of biological preservation technology were proposed.