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食品研究与开发:2024,45(7):174-180
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发酵食品中具有潜在降尿酸功能乳酸菌的筛选及特性分析
(1.佳木斯大学 公共卫生学院黑龙江省痛风研究重点实验室,黑龙江 佳木斯 154000;2.佳木斯大学附属第一医院 急诊科,黑龙江 佳木斯 154000;3.佳木斯大学 基础医学院 黑龙江省微生态-免疫调控网络与相关疾病重点实验室,黑龙江 佳木斯 154000;4.包头市疾病预防控制中心,内蒙古 包头 014030)
Screening and Characteristics Analysis of Lactic Acid Bacteria with Potential Function of Reducing Uric Acid from Fermented Foods
(1.Heilongjiang Key Laboratory of Gout Research,School of Public Health,Jiamusi University,Jiamusi 154000,Heilongjiang,China;2.Department of Emergency,The First Affiliated Hospital of Jiamusi University,Jiamusi 154000,Heilongjiang,China;3.Heilongjiang Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases,School of Basic Medical Sciences,Jiamusi University,Jiamusi 154000,Heilongjiang,China;4.Baotou Disease Prevention and Control Center,Baotou 014030,Inner Mongolia,China)
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投稿时间:2023-11-10    
中文摘要: 从传统发酵食品中筛选具有潜在降尿酸功能的乳酸菌,利用高效液相色谱法分析该菌株的核苷降解能力,并检测菌株对黄嘌呤氧化酶抑制作用、消化道环境耐受性及抗生素敏感性。结果表明:大酱中的植物乳杆菌(Lactobacillus plantarum)TY-S8 对核苷的降解率可达99.33%,对黄嘌呤氧化酶的抑制率可达16.73%,此外,在经pH2.0~4.0、3.0 g/L 胆盐以及人工胃肠条件处理下,其活菌数均可高达6.00 lg(CFU/mL)以上,且菌株对氨苄西林、红霉素以及头孢曲松具有较强敏感性。综上,植物乳杆菌TY-S8 具有潜在降尿酸功能以及良好的益生特性,可以应用于高尿酸血症预防和辅助治疗中。
中文关键词: 高尿酸血症  核苷  乳酸菌  植物乳杆菌  尿酸
Abstract:This paper isolated lactic acid bacteria capable of lowering uric acid from traditional fermented foods.The nucleoside degradation ability of the screened strains was analyzed by high performance liquid chromatography(HPLC),and their inhibition against xanthine oxidase,environmental tolerance in vitro and antibiotic susceptibility were also tested.The results showed that Lactobacillus plantarum TY-S8 from soybean paste was able to efficiently degrade nucleosides,with the degradation rate reaching as high as 99.33%,and the inhibition rate for xanthine oxidase could be as high as 16.73%.Additioinally,L.plantarum TY-S8 treated with 3.0 g/L bile salts and artificial gastrointestinal conditions at pH2.0-4.0 had viable bacterial counts over 6.00 lg(CFU/mL),and the strain was sensitive to some antibiotics such as ampicillin,erythromycin and ceftriaxone.In conclusion,L.plantarum TY-S8 had the potential function of reducing uric acid as well as desirable probiotic characteristics,which could be applied to the prevention and adjuvant treatment of hyperuricemia.
文章编号:202407024     中图分类号:    文献标志码:
基金项目:黑龙江省省属高等学校基本科研业务费科研项目(2022-KYYWF-0649)
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