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投稿时间：2018-09-09
投稿时间：2018-09-09
中文摘要: 研究决明子山药黄豆复配对SD大鼠高脂血症血脂代谢和肝脏脂肪变性的影响。采用高脂饲料喂养4周建立大鼠高脂血症模型后随机分组，阳性对照组采用阿托伐他汀灌胃给药，实验组采用决明子山药黄豆复配掺入高脂饲料喂养，观察决明子山药黄豆复配对其血脂和肝脏脂肪变性的影响。与空白对照组比较，模型组血清总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）水平显著升高（P＜0.05）；与模型组比较，中剂量决明子山药黄豆复配组血清TC、TG水平显著降低（P＜0.05），低、中、高剂量决明子山药黄豆复配组血清中LDL-C水平显著降低（P＜0.05），但各剂量组之间无明显差异。决明子山药黄豆复配可降低实验大鼠高脂饮食引起的高脂血症，以中剂量效果最为显著，无明显剂量效应关系。
Abstract:To study the effects of semen cassia yam soybean on hyperlipemia and liver fatty degeneration in rats.Rats were fed with high fat diet for four weeks to establish hyperlipemia model，then the rats were randomly divided into different groups，and the rats of positive control group were gavaged with atorvastatin and the rats of experimental groups were fed with semen cassia yam soybean of high fat diet.The effects of semen cassia yam soybean on hyperlipemia and liver fatty degeneration was observed in rats.Compared with blank control group，serum TC(total cholesterol)，TG(triglyceride)，HDL-C(high density lipoprotein cholesterol)and LDL-C(low density lipoprotein cholesterol)of model group significantly increased（P＜0.05）.Compared with model group，serum TC and TG of middle dose group were significantly reduced（P＜0.05）.Serum LDL-C of different doses of semen cassiae yam soybean was significantly reduced（P＜0.05），but no difference of different doses.Semen cassia yam soybean compound can decrease blood lipid of the hyperlipidemia rats with high-fat diet.The most significant effect is middle-dose and no obvious dose effect relationship in different doses.
文章编号：201905009 中图分类号： 文献标志码：
基金项目:西南医科大学与泸州市古蔺县科技局横向合作项目（0903-00010033）；泸州市创新苗子项目（2017-R-66）
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